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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The majority (≈75%) of liver cancer is HCC, making…

Histones (Chromosome condensation) HMG-1 (Chromosome condensation) RIIα (Chromosome condensation) Nir2 (Fragmentation of the Golgi network) p47 (Fragmentation of the Golgi…

IPL1  CLB2  CDC6  CDC20  MIH1  CDC8  CDH1/HCT1  CDC5  PDS1  SGO1  UBC11

The Cdk1-cyclin B1 kinase triggers mitosis in most eukaryotes.   The complex between Cdk1-cyclin B1 functions as a kinase (serine-threonine kinase)…

Anaphase refers to a phase in mitosis. In anaphase, the central spindle microtubules start to bundle and position the actomyosin…

The Anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that plays a crucial role in cell cycle regulation….

Cytokinesis is the last phase of the cell cycle that results in the generation of daughter cells. Cytokinesis is precisely…

Mitogenic signaling is required for cells to enter the cell cycle. In the absence of mitogenic signaling, cells stop division…

A typical cell division results in the generation of two identical daughter cells. Soon after formation, daughter cells either enter…

Integrin-mediated cell attachment to the extracellular matrix (ECM) has been shown to regulate the cell cycle.   Cell cycle phases, the…

Protein Name Separase Synonyms Separin Activity cysteine protease  Function Cleavage of cohesin proteins during mitosis, leading to separation of sister…

The cell cycle is a highly regulated process. The transition from G2 phase to M phase is characterized by the…

Jansen et al., 2023. live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle. J Cell Biol….

p21 is a crucial effector of p53. It is upregulated in response to cellular stress, in most cases through p53…