Category: Lab Notes
Cyclin D
D-type cyclins (or cyclin D)* are active in the G1 phase of the cell cycle. Their expression is induced by…
Restriction Point (R)
Growth factor/mitogenic signaling is required for G1 phase progress. Withdrawal of growth factors/mitogens from cell culture can arrest the cells…
G1 phase
The G1 phase begins with the generation of daughter cells following cytokinesis and ends when daughter cells are ready to…
Rb-mediated Suppression of Proliferation
Constitutive expression of cyclin A and E can overcome pRb-mediated suppression of proliferation (Hinds et al., 1992). REFERENCES Hinds et…
List of Kinases that can Phosphorylate Rb
The following kinases can phosphorylate Rb Cyclin D-CDK4 Cyclin D-CDK6 Cyclin E-CDK2 Stress-activated protein kinases of the p38 family
Topic: Cell Cycle and Proliferation
Cell Cycle Cell Proliferation Rb-mediated Suppression of Proliferation Cell Cycle Phases Interphase (Cell Cycle) M Phase (Cell Cycle) Antephase (Cell…
G0 phase
In some situations, proliferating cells stop cell division and exit the cell cycle in the G1 phase. These nonproliferative cells…
Interphase (Cell Cycle)
During cell division, dividing cells enter a complex and highly regulated series of events, the cell cycle, that result in…
Cell Cycle Phases
A typical mammalian cell cycle can have the following distinct phases: G1 phase S phase G2 phase M phase: Generation…
Chromosome Condensation During Mitosis
The first stage of mitosis Early stages of chromosome condensation in prophase are reversible in many organisms. The initiation of…
Cyclin B1 Subcellular Localization During Cell Cycle
During the G2 phase, cyclin B1 is localized in the cytoplasm. Cyclin B1 accumulation on centrosome start in the mid-G2…
Cyclin B1
Cyclin B1 is the main B-type cyclin, which regulates cell cycle progression during the transition from interphase to mitosis as…
Cyclin A Vs Cyclin B
Both Cyclin A and Cyclin B are considered mitotic cyclins. Both cyclins are synthesized and degraded around the same time…
List of CDK2-Cyclin E Substrates
NPAT (also known as p220) (Histone modification) HIRA (Histone modification) CBP/p300 (Histone modification) Cdt1 (DNA replication) BRCA1 (DNA repair) Ku70…
References: PD98059
Karayiannis et al., 2023. Induction of MMP-3 and MMP-9 expression during Helicobacter pylori infection via MAPK signaling pathways. Helicobacter. 28(4),…