Category: Lab Notes
List of Cell Lines Expressing High Levels of Cyclin D1
The following cell lines express relatively high levels of cyclin D1. MCF7 REFERENCES: Bienvenu et al., 2005. Transcriptional regulation by…
LY294002
Cas Noumber: 154447-36-6 Activities: Potent inhibitor of phosphoinositide 3-kinases (PI3Ks) Although it is a potent inhibitor of PI3K, it is…
Interaction of Cyclin D1 with STAT3
Cyclin D1 has been shown to interact with STAT3. This interaction is not direct and is mediated by NcoA/SRC1a (Bienvenu…
ExpSup: Cyclin D1 Inhibits p21 Gene Transcription
HepG2 cells stably expressing Cyclin D1 show a reduced level of p21 expression (both mRNA and protein) as compared to…
ExpSup: IL6 Induces p21 Transcription in Serum-Starved HepG2 Cell Line
Bienvenu and coworkers showed that stimulation of serum-starved HepG2 cells with IL6 induces p21 expression (Bienvenu et al., 2005). They…
Cyclin D in Cancer
Well-established oncogene Driver of tumors May confer resistance to chemotherapy Cyclin D overexpression, accumulation, and mislocalization have been reported in…
Activation of CDK4/6 in G1 Phase
Cyclin-dependent kinases CDK4 and CDK6 (CDK4/6) play important roles in controlling the G1 phase progression, particularly passing the cells through…
Cyclin-dependent Kinases (CDKs)
As the name suggests, these kinases are dependent on their regulatory subunit “Cyclins” to function as a kinase. Cyclin-dependent kinases…
List of Human Cyclin-Dependent Kinases (CDKs)
In humans, 20 Cyclin-Dependent Kinases have been reported. Cyclin-Dependent Kinase 1 (CDK1) Cyclin-Dependent Kinase 2 (CDK2) Cyclin-Dependent Kinase 3 (CDK3)…
Cyclin E1
Cyclin E1 is the first identified member of E-type cyclin. The other known member of E-type cyclin is cyclin E2….
List of Cyclin D-CDK4/6 Substrates
Cyclin D-CDK4 and Cyclin D-CDK6 holoenzymes are reported to phosphorylate the following proteins: pRB p107 p130 Smad3 FOXM1 Cdt1
Molecular Events Driving G1 Phase Progression
In contrast to other cell cycle phases, extracellular signaling from growth factors/mitogens is essential for G1 phase progression. These signaling…
RUNX3
Transcription factor Plays an important role in lineage determination Functions as a tumor suppressor Regulator of cell cycle and apoptosis…
Cyclin D
D-type cyclins (or cyclin D)* are active in the G1 phase of the cell cycle. Their expression is induced by…